應(yīng)用微波輻射合成14-Helicalβ-Peptides

更新時(shí)間：2009-08-04 點(diǎn)擊次數(shù)：2534

Abstract:

We have evaluated the effects of microwave irradiation on the solid-phase synthesis of B-peptides.

Sequences designed to adopt the 14-helix, especially those containing the structure – promoting

residue trans-2-aminocyclohexanecarboxylix acid （ACHC）, suffer from poor synthetic efficiency

under standard SPPS conditions. A comparision of microwave and conventional heating shows

that both provide excellent synthetic results for shorter sequences; however, we identify a clear

benefit from microwave irradiation for longer B-peptides.

應(yīng)用微波輻射合成14-Helicalβ-Peptides

摘要：

我們已經(jīng)評(píng)估微波輻射對(duì)固相合成B-peptides的影響。在標(biāo)準(zhǔn)SPPS條件下, 序列用作吸納14-螺旋（14- Helix）是存在非常低的合成效率，尤其是那些含有trans-2-aminocyclohexanecarboxylix acid （ACHC）殘余物的結(jié)構(gòu)。比較微波加熱和常規(guī)加熱表明，兩者都能為合成短序列多肽提供的綜合成果;但是，我們確定微波輻射也能夠?yàn)楹铣奢^長(zhǎng)的乙肽（β- Peptides）提供的綜合成果。

微波合成

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應(yīng)用微波輻射合成14-Helicalβ-Peptides